Fasting Serum Lipid and Dehydroepiandrosterone Sulfate as Important Metabolites for Detecting Isolated Postchallenge Diabetes: Serum Metabolomics via Ultra-High-Performance LC-MS | Zendy

Liyan Liu | Zendy; Maoqing Wang | Zendy; Xue Yang | Zendy; Mingxin Bi | Zendy; Lixin Na | Zendy; Yucun Niu | Zendy; Ying Li | Zendy; Changhao Sun | Zendy

Open Access

Fasting Serum Lipid and Dehydroepiandrosterone Sulfate as Important Metabolites for Detecting Isolated Postchallenge Diabetes: Serum Metabolomics via Ultra-High-Performance LC-MS

Author(s) -

Liyan Liu,

Maoqing Wang,

Xue Yang,

Mingxin Bi,

Lixin Na,

Yucun Niu,

Ying Li,

Changhao Sun

Publication year - 2013

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.200527

Subject(s) - linoleic acid , metabolite , metabolomics , medicine , diabetes mellitus , dehydroepiandrosterone sulfate , endocrinology , metabolome , oleic acid , chemistry , postprandial , chromatography , fatty acid , biochemistry , androgen , hormone

Isolated postchallenge diabetes (IPD), a subtype of type 2 diabetes mellitus (T2DM) defined as 2-h postprandial plasma glucose ≥ 200 mg/dL (≥ 11.1 mmol/L) and fasting plasma glucose (FPG) <108 mg/dL (<6.0 mmol/L), is often overlooked during screening for diabetes on the basis of FPG concentrations. A key challenge is early identification of IPD by the use of fasting serum, which is critical for large-scale diabetes screening.

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