Inhibition of the Renin-Angiotensin System Reduces the Rise in Serum Aldosterone in Acute Coronary Syndrome Patients with Preserved Left Ventricular Function: Observations from the AVANT GARDE-TIMI 43 Trial | Zendy

Jacob A. Udell | Zendy; David A. Morrow | Zendy; Eugene Braunwald | Zendy; Karl Swedberg | Zendy; Christoph Bode | Zendy; Nader Rifai | Zendy; Patrick Brunel | Zendy; Margaret F. Prescott | Zendy; Fang Ren | Zendy; Elaine Hoffman | Zendy; Benjamin M. Scirica | Zendy

Open Access

Inhibition of the Renin-Angiotensin System Reduces the Rise in Serum Aldosterone in Acute Coronary Syndrome Patients with Preserved Left Ventricular Function: Observations from the AVANT GARDE-TIMI 43 Trial

Author(s) -

Jacob A. Udell,

David A. Morrow,

Eugene Braunwald,

Karl Swedberg,

Christoph Bode,

Nader Rifai,

Patrick Brunel,

Margaret F. Prescott,

Fang Ren,

Elaine Hoffman,

Benjamin M. Scirica

Publication year - 2013

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.199729

Subject(s) - aldosterone , valsartan , aliskiren , medicine , cardiology , myocardial infarction , placebo , renin–angiotensin system , endocrinology , interquartile range , angiotensin ii , urology , blood pressure , pathology , alternative medicine

Acute coronary syndrome (ACS) activates neurohormonal pathways, including elevations in circulating aldosterone, with deleterious cardiovascular effects. We aimed to determine if early, more complete renin-angiotensin-aldosterone system inhibition (RAASI) in post-ACS patients without ventricular dysfunction or heart failure would result in a graded reduction in aldosterone concentrations.

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