Evolving Role of Microparticles in the Pathophysiology of Endothelial Dysfunction | Zendy

Fina Lovren | Zendy; Subodh Verma | Zendy

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Evolving Role of Microparticles in the Pathophysiology of Endothelial Dysfunction

Author(s) -

Fina Lovren,

Subodh Verma

Publication year - 2013

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.199711

Subject(s) - endothelial dysfunction , endothelium , inflammation , endothelial stem cell , proinflammatory cytokine , angiogenesis , population , medicine , immunology , endothelial activation , biology , cancer research , in vitro , biochemistry , environmental health

Endothelial dysfunction is an early event in the development and progression of a wide range of cardiovascular diseases. Various human studies have identified that measures of endothelial dysfunction may offer prognostic information with respect to vascular events. Microparticles (MPs) are a heterogeneous population of small membrane fragments shed from various cell types. The endothelium is one of the primary targets of circulating MPs, and MPs isolated from blood have been considered biomarkers of vascular injury and inflammation.

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