Methods for Measuring Serum Activity Levels of the 192 Q and R Isoenzymes of Paraoxonase 1 in QR Heterozygous Individuals | Zendy

John F. Teiber | Zendy; Gerald L. Kramer | Zendy; Robert W. Haley | Zendy

Open Access

Methods for Measuring Serum Activity Levels of the 192 Q and R Isoenzymes of Paraoxonase 1 in QR Heterozygous Individuals

Author(s) -

John F. Teiber,

Gerald L. Kramer,

Robert W. Haley

Publication year - 2013

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.199331

Subject(s) - isozyme , paraoxonase , aryldialkylphosphatase , heterozygote advantage , medicine , chemistry , biochemistry , enzyme , genotype , pon1 , gene

Paraoxonase 1 (PON1), an esterase that hydrolyzes toxic organophosphates and has antioxidative and antiatherogenic properties, contains a common polymorphism at position 192: glutamine (Q) or arginine (R). The Q and R isoenzymes exhibit different physical and protective properties. We describe 2 methods for quantifying their serum activity levels.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research