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Association of Apolipoprotein B and Nuclear Magnetic Resonance Spectroscopy–Derived LDL Particle Number with Outcomes in 25 Clinical Studies: Assessment by the AACC Lipoprotein and Vascular Diseases Division Working Group on Best Practices
Author(s) -
Thomas Cole,
John H. Contois,
György Csákó,
Joseph P. McConnell,
Alan T. Remaley,
Sridevi Devaraj,
Daniel M Hoefner,
Tonya Mallory,
Amar A Sethi,
G. Russell Warnick
Publication year - 2013
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2012.196733
Subject(s) - apolipoprotein b , association (psychology) , lipoprotein particle , medicine , division (mathematics) , lipoprotein , psychology , very low density lipoprotein , cholesterol , mathematics , arithmetic , psychotherapist
The number of circulating LDL particles is a strong indicator of future cardiovascular disease (CVD) events, even superior to the concentration of LDL cholesterol. Atherogenic (primarily LDL) particle number is typically determined either directly by the serum concentration of apolipoprotein B (apo B) or indirectly by nuclear magnetic resonance (NMR) spectroscopy of serum to obtain NMR-derived LDL particle number (LDL-P).

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