Open AccessEstablishment and Validation of Analytical Reference Panels for the Standardization of Quantitative BCR-ABL1 Measurements on the International Scale
Author(s) -
Helen White,
John Hedges,
Israel Bendit,
Susan Branford,
Dolors Colomer,
Andreas Hochhaus,
Timothy P. Hughes,
Suzanne KamelReid,
DongWook Kim,
Vijay Modur,
Martin Müller,
Kátia Bórgia Barbosa Pagnano,
Fabrizio Pane,
Jerry Radich,
Nicholas C.P. Cross,
Emmanuel Labourier
Publication year - 2013
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2012.196477
Subject(s) - standardization , abl , breakpoint cluster region , certified reference materials , computer science , computational biology , reliability engineering , medicine , mathematics , statistics , biology , engineering , tyrosine kinase , detection limit , receptor , operating system
Current guidelines for managing Philadelphia-positive chronic myeloid leukemia include monitoring the expression of the BCR-ABL1 (breakpoint cluster region/c-abl oncogene 1, non-receptor tyrosine kinase) fusion gene by quantitative reverse-transcription PCR (RT-qPCR). Our goal was to establish and validate reference panels to mitigate the interlaboratory imprecision of quantitative BCR-ABL1 measurements and to facilitate global standardization on the international scale (IS).
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