Measurement of Thyroglobulin by Liquid Chromatography–Tandem Mass Spectrometry in Serum and Plasma in the Presence of Antithyroglobulin Autoantibodies | Zendy

Mark M. Kushnir | Zendy; Alan L. Rockwood | Zendy; William L. Roberts | Zendy; Dev Abraham | Zendy; Andrew N. Hoofnagle | Zendy; A.W. Meikle | Zendy

Open Access

Measurement of Thyroglobulin by Liquid Chromatography–Tandem Mass Spectrometry in Serum and Plasma in the Presence of Antithyroglobulin Autoantibodies

Author(s) -

Mark M. Kushnir,

Alan L. Rockwood,

William L. Roberts,

Dev Abraham,

Andrew N. Hoofnagle,

A.W. Meikle

Publication year - 2013

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.195594

Subject(s) - thyroglobulin , chromatography , chemistry , autoantibody , liquid chromatography–mass spectrometry , tandem mass spectrometry , mass spectrometry , polyclonal antibodies , detection limit , standard curve , medicine , antibody , thyroid , immunology

Measurement of serum thyroglobulin (Tg) is used to monitor patients after treatment for differentiated thyroid carcinoma (TC). Difficulty in using Tg as a biomarker of the recurrence of TC in many patients stems from the presence of endogenous anti-Tg autoantibodies (Tg-AAbs), which can interfere with immunoassays (IAs) and cause false-negative results.

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