Evaluation of a Dried Blood Spot Assay to Measure Prenatal Screening Markers Pregnancy-Associated Plasma Protein A and Free β-Subunit of Human Chorionic Gonadotropin | Zendy

Nicholas J. Cowans | Zendy; Mikko Suonpää | Zendy; Heikki Kouru | Zendy; D. Wright | Zendy; Kevin Spencer | Zendy

Open Access

Evaluation of a Dried Blood Spot Assay to Measure Prenatal Screening Markers Pregnancy-Associated Plasma Protein A and Free β-Subunit of Human Chorionic Gonadotropin

Author(s) -

Nicholas J. Cowans,

Mikko Suonpää,

Heikki Kouru,

D. Wright,

Kevin Spencer

Publication year - 2013

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.194894

Subject(s) - dried blood spot , human chorionic gonadotropin , dried blood , prenatal screening , gonadotropin , blood proteins , andrology , endocrinology , pregnancy associated plasma protein a , chemistry , medicine , blood plasma , pregnancy , first trimester , biology , fetus , prenatal diagnosis , chromatography , hormone , genetics

First-trimester prenatal screening for aneuploidy by use of dried blood spots (DBSs) may offer practical benefits in settings where the instability of intact human chorionic gonadotropin (hCG) is problematic. We evaluated a DBS pregnancy-associated plasma protein A (PAPP-A) and free β-subunit of hCG (free hCGβ) dual assay and compared it to serum screening.

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