Alternative Calibration Strategies for the Clinical Laboratory: Application to Nortriptyline Therapeutic Drug Monitoring | Zendy

Matthew T. Olson | Zendy; Autumn Breaud | Zendy; Robert Harlan | Zendy; Nkechinyere Emezienna | Zendy; Sabitha Schools | Zendy; Alfred L. Yergey | Zendy; Danni Li | Zendy

Open Access

Alternative Calibration Strategies for the Clinical Laboratory: Application to Nortriptyline Therapeutic Drug Monitoring

Author(s) -

Matthew T. Olson,

Autumn Breaud,

Robert Harlan,

Nkechinyere Emezienna,

Sabitha Schools,

Alfred L. Yergey,

Danni Li

Publication year - 2013

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.194639

Subject(s) - calibration , calibration curve , analyte , medicine , area under the curve , chromatography , therapeutic drug monitoring , analytical chemistry (journal) , chemistry , pharmacology , pharmacokinetics , mathematics , detection limit , statistics

The addition of a calibration curve with every run is both time-consuming and expensive for clinical mass spectrometry assays. We present alternative calibration strategies that eliminate the need for a calibration curve except as required by laboratory regulations.

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