Copy Number and Expression Alterations of miRNAs in the Ovarian Cancer Cell Line OVCAR-3: Impact on Kallikrein 6 Protein Expression | Zendy

Jane Bayani | Zendy; Uroš Kuzmanov | Zendy; Punit Saraon | Zendy; William Fung | Zendy; Antoninus Soosaipillai | Zendy; Jeremy A. Squire | Zendy; Eleftherios P. Diamandis | Zendy

Open Access

Copy Number and Expression Alterations of miRNAs in the Ovarian Cancer Cell Line OVCAR-3: Impact on Kallikrein 6 Protein Expression

Author(s) -

Jane Bayani,

Uroš Kuzmanov,

Punit Saraon,

William Fung,

Antoninus Soosaipillai,

Jeremy A. Squire,

Eleftherios P. Diamandis

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.193060

Subject(s) - kallikrein , microrna , biology , gene , gene expression , gene expression profiling , locus (genetics) , comparative genomic hybridization , microbiology and biotechnology , genetics , computational biology , genome , biochemistry , enzyme

Kallikrein-related peptidase 6 (KLK6), a member of the serine protease family of kallikrein (KLK) genes, is dysregulated in ovarian carcinomas (OCa) and its overexpression is associated with poor prognosis. Regulation of its expression is poorly understood and is likely to be influenced by multiple mechanisms. The KLK locus is subject to copy number changes and heterogeneity in serous OCas. These copy number imbalances generally correlate with KLK6 protein expression; however, this is not always the case. In this study we explored the role of miRNAs in the posttranscriptional control of KLK6 expression and the contributions of copy numbers, not only of the KLK locus, but also of the miRNAs predicted to regulate it.

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