COLD-PCR and Innovative Microarray Substrates for Detecting and Genotyping MPL Exon 10 W515 Substitutions | Zendy

Angela Brisci | Zendy; Francesco Damin | Zendy; Daniela Pietra | Zendy; Silvia Galbiati | Zendy; Sabrina Boggi | Zendy; Ilaria Carola Casetti | Zendy; Elisa Rumi | Zendy; Marcella Chiari | Zendy; Mario Cazzola | Zendy; Maurizio Ferrari | Zendy; Laura Cremonesi | Zendy

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COLD-PCR and Innovative Microarray Substrates for Detecting and Genotyping MPL Exon 10 W515 Substitutions

Author(s) -

Angela Brisci,

Francesco Damin,

Daniela Pietra,

Silvia Galbiati,

Sabrina Boggi,

Ilaria Carola Casetti,

Elisa Rumi,

Marcella Chiari,

Mario Cazzola,

Maurizio Ferrari,

Laura Cremonesi

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.192708

Subject(s) - genotyping , exon , genetics , biology , microarray , polymerase chain reaction , microbiology and biotechnology , gene , genotype , computational biology , gene expression

Myeloproliferative neoplasms (MPNs) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Somatic mutations in exon 10 of the MPL (myeloproliferative leukemia virus oncogene) gene, mainly substitutions encoding W515 variants, have recently been described in a minority of patients with ET or PMF. We optimized analytically sensitive methods for detecting and genotyping MPL variants.

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