SOX17 Promoter Methylation in Circulating Tumor Cells and Matched Cell-Free DNA Isolated from Plasma of Patients with Breast Cancer | Zendy

Maria Chimonidou | Zendy; Αreti Strati | Zendy; Nikos Malamos | Zendy; Vasilis Georgoulias | Zendy; Evi Lianidou | Zendy

Open Access

SOX17 Promoter Methylation in Circulating Tumor Cells and Matched Cell-Free DNA Isolated from Plasma of Patients with Breast Cancer

Author(s) -

Maria Chimonidou,

Αreti Strati,

Nikos Malamos,

Vasilis Georgoulias,

Evi Lianidou

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.191551

Subject(s) - dna methylation , methylation , breast cancer , circulating tumor cell , metastatic breast cancer , cancer , medicine , bisulfite sequencing , oncology , cell free fetal dna , cancer research , metastasis , liquid biopsy , biology , dna , gene , gene expression , genetics , pregnancy , fetus , prenatal diagnosis

Detection of circulating tumor cells (CTCs) and cell-free DNA (cfDNA) in the peripheral blood of patients with solid tumors has been widely studied for the early detection of metastatic spread. We evaluated whether there was an association between the origin of cfDNA and CTCs. We investigated whether SRY (sex determining region Y)-box 17 (SOX17) promoter methylation in CTCs was associated with the methylation pattern of this gene in matched cfDNA isolated from plasma of patients with breast cancer.

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