Downregulation and Prognostic Performance of MicroRNA 224 Expression in Prostate Cancer
Author(s) -
Konstantinos Mavridis,
Konstantinos Stravodimos,
Andreas Scorilas
Publication year - 2012
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2012.191502
Subject(s) - prostate cancer , oncology , pca3 , biomarker , medicine , microrna , overdiagnosis , prostate , cancer , proportional hazards model , biology , gene , biochemistry
The extensive use of prostate-specific antigen as a general prostate cancer biomarker has introduced the hazards of overdiagnosis and overtreatment. Recent studies have revealed the immense biomarker capacity of microRNAs (miRNAs) in prostate cancer. The aim of this study was to analyze the expression pattern of miR-224, a cancer-related miRNA, in prostate tumors and investigate its clinical utility.
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