Heterogeneity of Epidermal Growth Factor Receptor Status and Mutations of KRAS/PIK3CA in Circulating Tumor Cells of Patients with Colorectal Cancer | Zendy

Christin Gasch | Zendy; Thomas Bauernhofer | Zendy; Martin Pichler | Zendy; Sabine Langer-Freitag | Zendy; Matthias Reeh | Zendy; Adrian M. Seifert | Zendy; Oliver Mauermann | Zendy; Jakob R. Izbicki | Zendy; Klaus Pantel | Zendy; Sabine Riethdorf | Zendy

Open Access

Heterogeneity of Epidermal Growth Factor Receptor Status and Mutations of KRAS/PIK3CA in Circulating Tumor Cells of Patients with Colorectal Cancer

Author(s) -

Christin Gasch,

Thomas Bauernhofer,

Martin Pichler,

Sabine Langer-Freitag,

Matthias Reeh,

Adrian M. Seifert,

Oliver Mauermann,

Jakob R. Izbicki,

Klaus Pantel,

Sabine Riethdorf

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.188557

Subject(s) - kras , colorectal cancer , circulating tumor cell , cancer research , epidermal growth factor receptor , oncogene , viral oncogene , cancer , medicine , biology , oncology , metastasis , cell cycle

Molecular characterization of circulating tumor cells (CTCs) is pivotal to increasing the diagnostic specificity of CTC assays and investigating therapeutic targets and their downstream pathways on CTCs. We focused on epidermal growth factor receptor (EGFR) and genes relevant for its inhibition in patients with colorectal cancer (CRC).

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