Confidence Intervals and Power Calculations for Within-Person Biological Variation: Effect of Analytical Imprecision, Number of Replicates, Number of Samples, and Number of Individuals | Zendy

Thomas Røraas | Zendy; Per Hyltoft Petersen | Zendy; Sverre Sandberg | Zendy

Open Access

Confidence Intervals and Power Calculations for Within-Person Biological Variation: Effect of Analytical Imprecision, Number of Replicates, Number of Samples, and Number of Individuals

Author(s) -

Thomas Røraas,

Per Hyltoft Petersen,

Sverre Sandberg

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.187781

Subject(s) - statistics , variation (astronomy) , reliability (semiconductor) , variance (accounting) , coefficient of variation , mathematics , sample size determination , statistical power , quality (philosophy) , power (physics) , computer science , physics , accounting , quantum mechanics , astrophysics , business , philosophy , epistemology

Reliable estimates of within-person biological variation and reference change value are of great importance when interpreting test results, monitoring patients, and setting quality specifications. Little information has been published regarding what experimental design is optimal to achieve the best estimates of within-person biological variation.

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