Circulating Human Hepcidin-25 Concentrations Display a Diurnal Rhythm, Increase with Prolonged Fasting, and Are Reduced by Growth Hormone Administration | Zendy

Jason S. Troutt | Zendy; Mats Rudling | Zendy; Lena Persson | Zendy; Lars Ståhle | Zendy; Bo Angelin | Zendy; Anthony Butterfield | Zendy; Andrew E. Schade | Zendy; Guoqing Cao | Zendy; Robert J. Konrad | Zendy

Open Access

Circulating Human Hepcidin-25 Concentrations Display a Diurnal Rhythm, Increase with Prolonged Fasting, and Are Reduced by Growth Hormone Administration

Author(s) -

Jason S. Troutt,

Mats Rudling,

Lena Persson,

Lars Ståhle,

Bo Angelin,

Anthony Butterfield,

Andrew E. Schade,

Guoqing Cao,

Robert J. Konrad

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.186866

Subject(s) - hepcidin , erythropoiesis , endocrinology , medicine , hormone , anemia

Hepcidin-25 reduces iron absorption by binding to the intestinal iron transporter ferroportin and causing its degradation. Currently, little is known about the basal regulation of circulating hepcidin-25. In addition, although erythropoietin administration has been reported to decrease the circulating hepcidin concentration, information is limited regarding how other stimulators of erythropoiesis, such as growth hormone (GH), might alter hepcidin-25 concentrations.

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