Nanofluidic Digital PCR for KRAS Mutation Detection and Quantification in Gastrointestinal Cancer | Zendy

Daniel Azuara | Zendy; Mireia M. Ginestà | Zendy; Mireia Gausachs | Zendy; Francisco RodríguezMoranta | Zendy; Joan Fabregat | Zendy; Juli Busquets | Zendy; Núria Peláez | Zendy; Jaume Boadas | Zendy; Sara Galter | Zendy; Vı́ctor Moreno | Zendy; José Costa | Zendy; Javier de | Zendy; Gabriel Capellá | Zendy

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Nanofluidic Digital PCR for KRAS Mutation Detection and Quantification in Gastrointestinal Cancer

Author(s) -

Daniel Azuara,

Mireia M. Ginestà,

Mireia Gausachs,

Francisco RodríguezMoranta,

Joan Fabregat,

Juli Busquets,

Núria Peláez,

Jaume Boadas,

Sara Galter,

Vı́ctor Moreno,

José Costa,

Javier de,

Gabriel Capellá

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.186577

Subject(s) - digital polymerase chain reaction , kras , colorectal cancer , allele , pancreatic cancer , mutant , pancreatitis , biology , polymerase chain reaction , cancer , real time polymerase chain reaction , mutation , cancer research , gastroenterology , medicine , pathology , gene , genetics

Concomitant quantification of multiple mutant KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) alleles may provide information in addition to that provided by standard mutation-detection procedures. We assessed the feasibility of a nanofluidic digital PCR array platform to detect and quantify KRAS mutations simultaneously in clinically relevant samples.

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