Cell Plasticity and Heterogeneity in Cancer | Zendy

Nemanja D. Marjanovic | Zendy; Robert A. Weinberg | Zendy; Christine L. Chaffer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cell Plasticity and Heterogeneity in Cancer

Author(s) -

Nemanja D. Marjanovic,

Robert A. Weinberg,

Christine L. Chaffer

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.184655

Subject(s) - cancer stem cell , somatic evolution in cancer , biology , phenotype , epigenetics , cancer , cancer cell , cancer research , cell division , tumor initiation , tumor progression , phenotypic plasticity , genetics , metastasis , cell , gene

Heterogeneity within a given cancer arises from diverse cell types recruited to the tumor and from genetic and/or epigenetic differences amongst the cancer cells themselves. These factors conspire to create a disease with various phenotypes. There are 2 established models of cancer development and progression to metastatic disease. These are the clonal evolution and cancer stem cell models.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research