Translating Genomics to the Clinic: Implications of Cancer Heterogeneity | Zendy

Nardin Samuel | Zendy; Thomas J. Hudson | Zendy

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Translating Genomics to the Clinic: Implications of Cancer Heterogeneity

Author(s) -

Nardin Samuel,

Thomas J. Hudson

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2012.184580

Subject(s) - context (archaeology) , genomics , genome , dna sequencing , personalized medicine , computational biology , precision medicine , cancer , personal genomics , cancer genome sequencing , whole genome sequencing , biology , data science , bioinformatics , computer science , genetics , gene , paleontology

Sequencing of cancer genomes has become a pivotal method for uncovering and understanding the deregulated cellular processes driving tumor initiation and progression. Whole-genome sequencing is evolving toward becoming less costly and more feasible on a large scale; consequently, thousands of tumors are being analyzed with these technologies. Interpreting these data in the context of tumor complexity poses a challenge for cancer genomics.

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