Variation of Cardiac Troponin I and T Measured with Sensitive Assays in Emergency Department Patients with Noncardiac Chest Pain | Zendy

Volkher Scharnhorst | Zendy; Krisztina Krasznai | Zendy; Marcel van ’t Veer | Zendy; Rolf Michels | Zendy

Open Access

Variation of Cardiac Troponin I and T Measured with Sensitive Assays in Emergency Department Patients with Noncardiac Chest Pain

Author(s) -

Volkher Scharnhorst,

Krisztina Krasznai,

Marcel van ’t Veer,

Rolf Michels

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.179903

Subject(s) - troponin complex , medicine , cardiology , myocardial infarction , troponin i , emergency department , troponin , chest pain , acute coronary syndrome , roche diagnostics , troponin t , psychiatry

New-generation high-sensitivity assays for cardiac troponin have lower detection limits and less imprecision than earlier assays. Reference 99th-percentile cutoff values for these new assays are also lower, leading to higher frequencies of positive test results. When cardiac troponin concentrations are minimally increased, serial testing allows discrimination of myocardial infarction from other causes of increased cardiac troponin. We assessed various measures of short-term variation, including absolute concentration changes, reference change values (RCVs), and indices of individuality (II) for 2 cardiac troponin assays in emergency department (ED) patients.

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