Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children | Zendy

David Colantonio | Zendy; Lianna Kyriakopoulou | Zendy; Man Khun Chan | Zendy; Caitlin Daly | Zendy; Davor Brinc | Zendy; Allison A. Venner | Zendy; Maria Pasic | Zendy; David Armbruster | Zendy; Khosrow Adeli | Zendy

Open Access

Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children

Author(s) -

David Colantonio,

Lianna Kyriakopoulou,

Man Khun Chan,

Caitlin Daly,

Davor Brinc,

Allison A. Venner,

Maria Pasic,

David Armbruster,

Khosrow Adeli

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.177741

Subject(s) - medicine , ethnic group , confidence interval , reference values , population , pediatrics , demography , database , family medicine , gerontology , environmental health , sociology , anthropology , computer science

Pediatric healthcare is critically dependent on the availability of accurate and precise laboratory biomarkers of pediatric disease, and on the availability of reference intervals to allow appropriate clinical interpretation. The development and growth of children profoundly influence normal circulating concentrations of biochemical markers and thus the respective reference intervals. There are currently substantial gaps in our knowledge of the influences of age, sex, and ethnicity on reference intervals. We report a comprehensive covariate-stratified reference interval database established from a healthy, nonhospitalized, and multiethnic pediatric population.

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