Four-Color Alternating-Laser Excitation Single-Molecule Fluorescence Spectroscopy for Next-Generation Biodetection Assays | Zendy

Seok W Yim | Zendy; Taiho Kim | Zendy; Ted A. Laurence | Zendy; Steve Partono | Zendy; Dongsik Kim | Zendy; Young-Gyu Kim | Zendy; Shimon Weiss | Zendy; Armin Reitmair | Zendy

Open Access

Four-Color Alternating-Laser Excitation Single-Molecule Fluorescence Spectroscopy for Next-Generation Biodetection Assays

Author(s) -

Seok W Yim,

Taiho Kim,

Ted A. Laurence,

Steve Partono,

Dongsik Kim,

Young-Gyu Kim,

Shimon Weiss,

Armin Reitmair

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.176958

Subject(s) - förster resonance energy transfer , multiplexing , fluorescence , nucleic acid , biosensor , nanotechnology , computational biology , materials science , chemistry , biology , computer science , biochemistry , optics , physics , telecommunications

Single-molecule detection (SMD) technologies are well suited for clinical diagnostic applications by offering the prospect of minimizing precious patient sample requirements while maximizing clinical information content. Not yet available, however, is a universal SMD-based platform technology that permits multiplexed detection of both nucleic acid and protein targets and that is suitable for automation and integration into the clinical laboratory work flow.

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