Fluorescence Sensor for the Quantification of Unbound Bilirubin Concentrations | Zendy

Andrew H. Huber | Zendy; Baolong Zhu | Zendy; Thomas Kwan | Zendy; J. Patrick Kampf | Zendy; Thomas Hegyi | Zendy; Alan M. Kleinfeld | Zendy

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Fluorescence Sensor for the Quantification of Unbound Bilirubin Concentrations

Author(s) -

Andrew H. Huber,

Baolong Zhu,

Thomas Kwan,

J. Patrick Kampf,

Thomas Hegyi,

Alan M. Kleinfeld

Publication year - 2012

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.176412

Subject(s) - bilirubin , chemistry , fluorophore , fluorescence , peroxidase , chromatography , human serum albumin , biochemistry , enzyme , medicine , endocrinology , physics , quantum mechanics

Hyperbilirubinemia in jaundiced neonates is routinely assessed by use of total serum bilirubin. However, the unbound or free form (B(f)), not total bilirubin, crosses the blood-brain barrier and can be neurotoxic. Although the peroxidase-mediated oxidation of bilirubin can be used to measure plasma concentrations of B(f), this measurement is relatively complex and the assay is not routinely used. We describe a fluorescence sensor for quantifying B(f) in plasma.

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