Circulating Epithelial Cells in Patients with Benign Colon Diseases | Zendy

Klaus Pantel | Zendy; E. Denève | Zendy; David Nocca | Zendy; Amandine Coffy | Zendy; Jean-Pierre Vendrell | Zendy; Thierry Maudelondé | Zendy; Sabine Riethdorf | Zendy; Catherine AlixPanabières | Zendy

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Circulating Epithelial Cells in Patients with Benign Colon Diseases

Author(s) -

Klaus Pantel,

E. Denève,

David Nocca,

Amandine Coffy,

Jean-Pierre Vendrell,

Thierry Maudelondé,

Sabine Riethdorf,

Catherine AlixPanabières

Publication year - 2011

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.175570

Subject(s) - medicine , circulating tumor cell , colorectal cancer , epithelial cell adhesion molecule , antigen , pathology , cancer , immunology , metastasis

Detection of circulating tumor cells (CTCs) in the peripheral blood is a rapidly developing research field with clear clinical implications for the staging and monitoring of cancer patients. Current CTC assays, including the US Food and Drug Administration-cleared CellSearch® system, typically use markers [e.g., cytokeratins (CKs), the transmembrane protein EpCAM (epithelial cell adhesion molecule)] that are expressed on normal and malignant epithelial cells but not on the surrounding normal leukocytes.

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