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Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein for Differentiating Intracerebral Hemorrhage and Cerebral Ischemia in Patients with Symptoms of Acute Stroke
Author(s) -
Christian Foerch,
Marion Niessner,
Tobias Back,
Michael Bauerle,
Gian Marco De Marchis,
A. Ferbert,
H. Grehl,
Gerhard F. Hamann,
Andréas H. Jacobs,
Andreas Kastrup,
Sven Klimpe,
Frederick Palm,
Götz Thomalla,
Hans Worthmann,
Matthias Sitzer
Publication year - 2011
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2011.172676
Subject(s) - medicine , intracerebral hemorrhage , glial fibrillary acidic protein , stroke (engine) , interquartile range , biomarker , brain ischemia , ischemic stroke , prospective cohort study , ischemia , gastroenterology , subarachnoid hemorrhage , immunohistochemistry , mechanical engineering , biochemistry , chemistry , engineering
Glial fibrillary acidic protein (GFAP) is a biomarker candidate indicative of intracerebral hemorrhage (ICH) in patients with symptoms of acute stroke. GFAP is released rapidly in the presence of expanding intracerebral bleeding, whereas a more gradual release occurs in ischemic stroke. In this study the diagnostic accuracy of plasma GFAP was determined in a prospective multicenter approach.

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