Lectin-like Oxidized LDL Receptor 1 Is Involved in CRP-Mediated Complement Activation | Zendy

Yoshiko Fujita | Zendy; Saburo Yamaguchi | Zendy; Akemi Kakino | Zendy; Shin Iwamoto | Zendy; Ryo Yoshimoto | Zendy; Tatsuya Sawamura | Zendy

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Lectin-like Oxidized LDL Receptor 1 Is Involved in CRP-Mediated Complement Activation

Author(s) -

Yoshiko Fujita,

Saburo Yamaguchi,

Akemi Kakino,

Shin Iwamoto,

Ryo Yoshimoto,

Tatsuya Sawamura

Publication year - 2011

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.168625

Subject(s) - complement system , inflammation , lectin pathway , classical complement pathway , receptor , immunology , chemistry , c reactive protein , decay accelerating factor , antibody , medicine , biochemistry

C-reactive protein (CRP) is purported to be a risk factor that acts independently of LDL cholesterol in predicting all-cause mortality in patients with ischemic heart disease. Lectin-like oxidized LDL receptor 1 (LOX-1) impairs endothelial function and exacerbates myocardial injury. We recently demonstrated that CRP increased vascular permeability through direct binding to LOX-1. Here we examined, using a hypertensive rat model, whether LOX-1 is involved in CRP-induced complement activation.

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