Specific Immunoassay Reveals Increased Serum Trypsinogen 3 in Acute Pancreatitis | Zendy

Jani Oiva | Zendy; Outi Itkonen | Zendy; Riitta Koistinen | Zendy; Kristina Hotakainen | Zendy; Wangming Zhang | Zendy; Esko Kemppainen | Zendy; Pauli Puolakkainen | Zendy; Leena Kylänpää | Zendy; UlfHåkan Stenman | Zendy; Hannu Koistinen | Zendy

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Specific Immunoassay Reveals Increased Serum Trypsinogen 3 in Acute Pancreatitis

Author(s) -

Jani Oiva,

Outi Itkonen,

Riitta Koistinen,

Kristina Hotakainen,

Wangming Zhang,

Esko Kemppainen,

Pauli Puolakkainen,

Leena Kylänpää,

UlfHåkan Stenman,

Hannu Koistinen

Publication year - 2011

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.167965

Subject(s) - trypsinogen , immunoassay , acute pancreatitis , pancreatitis , medicine , endocrinology , gastroenterology , chemistry , immunology , antibody , biochemistry , enzyme , trypsin

Trypsinogen 3 is a minor trypsinogen isoform in the pancreas. In contrast with trypsin 1 and 2, trypsin 3 degrades pancreatic secretory trypsin inhibitor, which may lead to an excess of active trypsin and acute pancreatitis (AP). We developed an immunoassay for trypsinogen 3 and studied whether an assay of serum trypsinogen 3 is of clinical utility in the diagnosis of AP.

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