The Impact of Delayed Storage on the Measured Proteome and Metabolome of Human Cerebrospinal Fluid | Zendy

Therese Rosenling | Zendy; Marcel P. Stoop | Zendy; Agnieszka Smolinska | Zendy; Bas Muilwijk | Zendy; L Coulier | Zendy; Shanna Shi | Zendy; Adrie Dane | Zendy; Christin Christin | Zendy; Frank Suits | Zendy; Péter Horvatovich | Zendy; Sybren S. Wijmenga | Zendy; L.M.C. Buydens | Zendy; Rob J. Vreeken | Zendy; Thomas Hankemeier | Zendy; Alain J. van Gool | Zendy; Theo M. Luider | Zendy; Rainer Bischoff | Zendy

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The Impact of Delayed Storage on the Measured Proteome and Metabolome of Human Cerebrospinal Fluid

Author(s) -

Therese Rosenling,

Marcel P. Stoop,

Agnieszka Smolinska,

Bas Muilwijk,

L Coulier,

Shanna Shi,

Adrie Dane,

Christin Christin,

Frank Suits,

Péter Horvatovich,

Sybren S. Wijmenga,

L.M.C. Buydens,

Rob J. Vreeken,

Thomas Hankemeier,

Alain J. van Gool,

Theo M. Luider,

Rainer Bischoff

Publication year - 2011

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.167601

Subject(s) - metabolome , proteome , chromatography , cystatin c , cerebrospinal fluid , chemistry , metabolomics , centrifugation , proteomics , mass spectrometry , liquid chromatography–mass spectrometry , tandem mass spectrometry , biomarker discovery , metabolite , sample preparation , biochemistry , biology , creatinine , neuroscience , gene

Because cerebrospinal fluid (CSF) is in close contact with diseased areas in neurological disorders, it is an important source of material in the search for molecular biomarkers. However, sample handling for CSF collected from patients in a clinical setting might not always be adequate for use in proteomics and metabolomics studies.

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