Point: Put Simply, Standardization of Cardiac Troponin I Is Complicated

The manuscript presents the point of view in favour of standardisation in a point-counterpoint article series in Clinical Chemistry. The article stresses the importance of reference measurement procedures and defining appropriately the analytical target taking the particular biochemistry of troponin I, a very important hart infarction marker, into consideration. The biochemical challenges in troponin I standardisation and the concept followed by the IFCC working group aiming at the establishment of a reference system are described. The conclusion is drawn that standardisation of troponin I is complicated but possible and worth the effort seen the positive impact of a successful standardisation on clinical decision making and patient care.JRC.D.2-Reference material