Molecular Alterations during Progression of Prostate Cancer to Androgen Independence | Zendy

Punit Saraon | Zendy; Keith Jarvi | Zendy; Eleftherios P. Diamandis | Zendy

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Molecular Alterations during Progression of Prostate Cancer to Androgen Independence

Author(s) -

Punit Saraon,

Keith Jarvi,

Eleftherios P. Diamandis

Publication year - 2011

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.165977

Subject(s) - prostate cancer , androgen receptor , androgen , cancer research , cancer , prostate , medicine , endocrinology , biology , hormone

Prostate cancer is the most commonly diagnosed cancer among men in North America and is a leading cause of death. Standard treatments include androgen deprivation therapy, which leads to improved clinical outcomes. However, over time, most tumors become androgen independent and no longer respond to hormonal therapies. Several mechanisms have been implicated in the progression of prostate cancer to androgen independence.

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