Optimal Detection of Fetal Chromosomal Abnormalities by Massively Parallel DNA Sequencing of Cell-Free Fetal DNA from Maternal Blood | Zendy

Amy J. Sehnert | Zendy; Brian Rhees | Zendy; David Comstock | Zendy; Eileen de Feo | Zendy; Gabrielle Heilek | Zendy; John M. Burke | Zendy; Richard P. Rava | Zendy

Open Access

Optimal Detection of Fetal Chromosomal Abnormalities by Massively Parallel DNA Sequencing of Cell-Free Fetal DNA from Maternal Blood

Author(s) -

Amy J. Sehnert,

Brian Rhees,

David Comstock,

Eileen de Feo,

Gabrielle Heilek,

John M. Burke,

Richard P. Rava

Publication year - 2011

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.165910

Subject(s) - massive parallel sequencing , trisomy , karyotype , cell free fetal dna , dna sequencing , biology , fetus , chromosome 21 , chromosome , aneuploidy , genetics , prenatal diagnosis , dna , computational biology , gene , pregnancy

Massively parallel DNA sequencing of cell-free fetal DNA from maternal blood can detect fetal chromosomal abnormalities. Although existing algorithms focus on the detection of fetal trisomy 21 (T21), these same algorithms have difficulty detecting trisomy 18 (T18).

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