DNA Methylation of Tumor Suppressor and Metastasis Suppressor Genes in Circulating Tumor Cells | Zendy

Maria Chimonidou | Zendy; Αreti Strati | Zendy; Alexandra Tzitzira | Zendy; Georgia Sotiropoulou | Zendy; Nikos Malamos | Zendy; Vasilis Georgoulias | Zendy; Evi Lianidou | Zendy

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DNA Methylation of Tumor Suppressor and Metastasis Suppressor Genes in Circulating Tumor Cells

Author(s) -

Maria Chimonidou,

Αreti Strati,

Alexandra Tzitzira,

Georgia Sotiropoulou,

Nikos Malamos,

Vasilis Georgoulias,

Evi Lianidou

Publication year - 2011

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2011.165902

Subject(s) - dna methylation , circulating tumor cell , methylation , metastasis , biology , cancer research , breast cancer , metastasis suppressor , metastatic breast cancer , suppressor , metastasis suppressor gene , liquid biopsy , cancer , promoter , population , oncology , gene , medicine , gene expression , genetics , environmental health

Circulating tumor cells (CTCs) are associated with prognosis in a variety of human cancers and have been proposed as a liquid biopsy for follow-up examinations. We show that tumor suppressor and metastasis suppressor genes are epigenetically silenced in CTCs isolated from peripheral blood of breast cancer patients.

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