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To the Editor:Cardiac troponin is the marker of choice for evaluating myocardial injury (1). High-sensitivity assays improve analytical detection limits, thereby allowing concentrations to be measured in the majority of healthy individuals. This capability allows an assessment of biologic variation (BV)1 to determine what constitutes a clinically important change in the cardiac troponin concentration, a critical metric for identifying acute events. Such an event is often a myocardial infarction, but any acute cardiac injury can cause increasing and/or decreasing values (1). Accordingly, we evaluated BV for a recently developed high-sensitivity cardiac troponin I (hs-cTnI) assay (2) from Beckman Coulter. We performed this study with the same cohort used to define BV for the high-sensitivity cardiac troponin T (hs-cTnT) assay (3) and according to a protocol approved by our institutional review board.For assessment of short-term BV, we collected blood into serum separator tubes (Becton Dickinson) at 0, 1, 2, 3, and 4 h, centrifuged the tubes, and stored the serum samples immediately at −70 °C. …

Biologic Variation of a Novel Cardiac Troponin I Assay