Open AccessHuman Pro–B-Type Natriuretic Peptide Is Processed in the Circulation in a Rat Model
Author(s) -
Alexander G Semenov,
Karina R Seferian,
Natalia N Tamm,
М.М. Артемьева,
Alexander B. Postnikov,
A. Bereznikova,
Andrey N. Kara,
Medvedeva Na,
Alexey G Katrukha
Publication year - 2011
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2010.161125
Subject(s) - natriuretic peptide , circulation (fluid dynamics) , peptide , medicine , endocrinology , systemic circulation , chemistry , biochemistry , heart failure , mechanics , physics
The appearance of B-type natriuretic peptide (BNP) in the blood is ultimately caused by proteolytic processing of its precursor, proBNP. The mechanisms leading to the high plasma concentration of unprocessed proBNP are still poorly understood. The goals of the present study were to examine whether processing of proBNP takes place in the circulation and to evaluate the clearance rate of proBNP and proBNP-derived peptides.
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