Open AccessImmune Complexome Analysis of Serum and Its Application in Screening for Immune Complex Antigens in Rheumatoid Arthritis
Author(s) -
Kaname Ohyama,
Yukitaka Ueki,
Atsushi Kawakami,
Naoya Kishikawa,
Mami Tamai,
Makoto Osaki,
Shimeru Kamihira,
Kenichiro Nakashima,
Naotaka Kuroda
Publication year - 2011
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2010.157776
Subject(s) - immune system , antigen , rheumatoid arthritis , immunology , medicine , immune complex
Analysis of circulating immune complexes (CICs) produced during an immune response may be useful in elucidating some aspects of this process. Identification of antigens incorporated into CICs provides information that may be helpful in developing diagnostic and treatment strategies for autoimmune diseases, infection, cancer, and transplantation therapy, and such information might be more relevant than information on free antigens. Because CICs may contain many antigens, comprehensive identification and profiling of such antigens is more effective than immunoblotting detection.
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