Expression Profile of MicroRNAs in Serum: A Fingerprint for Esophageal Squamous Cell Carcinoma
Author(s) -
ChenYu Zhang,
Cheng Wang,
Xi Chen,
Cuihua Yang,
Ke Li,
Junjun Wang,
Juncheng Dai,
Zhibin Hu,
Xiaojun Zhou,
Longbang Chen,
Yanni Zhang,
Yanfang Li,
Hong Qiu,
Jicheng Xing,
Zhichao Liang,
Binhui Ren,
Yang Chen,
Ke Zen
Publication year - 2010
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2010.147553
Subject(s) - microrna , biomarker , carcinoembryonic antigen , esophageal squamous cell carcinoma , medicine , oncology , stage (stratigraphy) , carcinoma , biology , cancer research , cancer , gene , paleontology , biochemistry
Sensitive and specific biomarkers for the early detection of esophageal squamous cell carcinoma (ESCC) are urgently needed to reduce the high morbidity and mortality of the disease. The discovery of serum microRNAs (miRNAs) and their unique concentration profiles in patients with various diseases makes them attractive, novel noninvasive biomarkers for tumor diagnosis. In this study, we investigated the serum miRNA profile in ESCC patients to develop a novel diagnostic ESCC biomarker.
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