Evaluation of Oligonucleotide Sequence Capture Arrays and Comparison of Next-Generation Sequencing Platforms for Use in Molecular Diagnostics | Zendy

Nicole L. HoppmanChaney | Zendy; Lisa M. Peterson | Zendy; Eric W. Klee | Zendy; Sumit Middha | Zendy; Laura K. Courteau | Zendy; Matthew J. Ferber | Zendy

Open Access

Evaluation of Oligonucleotide Sequence Capture Arrays and Comparison of Next-Generation Sequencing Platforms for Use in Molecular Diagnostics

Author(s) -

Nicole L. HoppmanChaney,

Lisa M. Peterson,

Eric W. Klee,

Sumit Middha,

Laura K. Courteau,

Matthew J. Ferber

Publication year - 2010

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2010.145441

Subject(s) - sanger sequencing , dna sequencing , computational biology , oligonucleotide , sequence (biology) , massive parallel sequencing , molecular diagnostics , genome , biology , oligomer restriction , personal genomics , computer science , human genome , genetics , dna , gene

Next-generation DNA sequencing (NGS) techniques have the potential to revolutionize molecular diagnostics; however, a thorough evaluation of these technologies is necessary to ensure their performance meets or exceeds that of current clinical sequencing methods.

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