Open AccessCorrelation Between Methylphenidate and Ritalinic Acid Concentrations in Oral Fluid and Plasma
Author(s) -
Emilia Marchei,
Magı́ Farré,
Ricardo Pardo,
Óscar GarcíaAlgar,
Manuela Pellegrini,
Roberta Pacifici,
Simona Pichini
Publication year - 2010
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2009.138396
Subject(s) - oral administration , pharmacokinetics , metabolite , chemistry , ingestion , body fluid , pharmacology , saliva , medicine
We studied the excretion profile of methylphenidate (MPH) and its metabolite ritalinic acid (RA) in oral fluid and plasma, the oral fluid-to-plasma (OF/P) drug ratio, and the variations of oral fluid pH after drug administration.
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