Open AccessMicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions
Author(s) -
M. Chalret du Rieu,
Jérôme Torrisani,
Janick Sèlves,
Talal Al Saati,
Anny Souque,
Marlène Dufresne,
Gregory J. Tsongalis,
Arief A. Suriawinata,
Nicolas Carrère,
Louis Buscail,
Pierre Cordelier
Publication year - 2010
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2009.137364
Subject(s) - pancreatic intraepithelial neoplasia , kras , microrna , cancer research , pancreatic cancer , cancer , oncogene , biology , adenocarcinoma , pathology , biomarker , medicine , cell cycle , gene , colorectal cancer , biochemistry
Pancreatic ductal adenocarcinoma (PDAC) has the poorest overall prognosis among gastrointestinal cancers; however, curative resection in early-stage PDAC greatly improves survival rates, indicating the importance of early detection. Because abnormal microRNA production is commonly detected in cancer, we investigated noninvasive precursor pancreatic intraepithelial neoplasia (PanIN) lesions for microRNA production as a potential early biomarker of PDAC.
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