Iothalamate Quantification by Tandem Mass Spectrometry to Measure Glomerular Filtration Rate | Zendy

Jesse C. Seegmiller | Zendy; Bradley E. Burns | Zendy; Abdul H. Fauq | Zendy; Naveen Mukhtar | Zendy; John C. Lieske | Zendy; Timothy S. Larson | Zendy

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Iothalamate Quantification by Tandem Mass Spectrometry to Measure Glomerular Filtration Rate

Author(s) -

Jesse C. Seegmiller,

Bradley E. Burns,

Abdul H. Fauq,

Naveen Mukhtar,

John C. Lieske,

Timothy S. Larson

Publication year - 2010

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2009.133751

Subject(s) - chromatography , chemistry , urine , renal function , liquid chromatography–mass spectrometry , tandem mass spectrometry , centrifugation , capillary electrophoresis , mass spectrometry , biochemistry

Glomerular filtration rate (GFR) can be determined by measuring renal clearance of the radiocontrast agent iothalamate. Current analytic methods for quantifying iothalamate concentrations in plasma and urine using liquid chromatography or capillary electrophoresis have limitations such as long analysis times and susceptibility to interferences. We developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to overcome these limitations.

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