Open AccessPeptides Generated Ex Vivo from Serum Proteins by Tumor-Specific Exopeptidases Are Not Useful Biomarkers in Ovarian Cancer
Author(s) -
John F. Timms,
Rainer Cramer,
Stéphane Camuzeaux,
Ali Tiss,
Celia Smith,
Brian Burford,
Ilia Nouretdinov,
Dmitry Devetyarov,
Aleksandra GentryMaharaj,
Jeremy Ford,
Zhiyuan Luo,
Alex Gammerman,
Usha Me,
Ian Jacobs
Publication year - 2010
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2009.133363
Subject(s) - ex vivo , ovarian cancer , in vivo , cancer , medicine , computational biology , oncology , biology , microbiology and biotechnology
The serum peptidome may be a valuable source of diagnostic cancer biomarkers. Previous mass spectrometry (MS) studies have suggested that groups of related peptides discriminatory for different cancer types are generated ex vivo from abundant serum proteins by tumor-specific exopeptidases. We tested 2 complementary serum profiling strategies to see if similar peptides could be found that discriminate ovarian cancer from benign cases and healthy controls.
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