Cell-Free DNA as a Noninvasive Acute Rejection Marker in Renal Transplantation | Zendy

Vanessa García Moreira | Zendy; Belén Prieto García | Zendy; Jose M Baltar Martín | Zendy; Francisco Ortega Suárez | Zendy; Francisco V. Álvarez | Zendy

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Cell-Free DNA as a Noninvasive Acute Rejection Marker in Renal Transplantation

Author(s) -

Vanessa García Moreira,

Belén Prieto García,

Jose M Baltar Martín,

Francisco Ortega Suárez,

Francisco V. Álvarez

Publication year - 2009

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2009.129072

Subject(s) - transplantation , procalcitonin , medicine , creatinine , cell free fetal dna , renal function , kidney transplantation , gastroenterology , urine , sepsis , immunology , biology , pregnancy , fetus , prenatal diagnosis , genetics

Acute rejection (AR) is a key conditioning factor for long-term graft function and survival in renal transplantation patients. The standard care with creatinine measurements and biopsy upon allograft dysfunction implies that AR is usually detected at advanced stages. Rapid noninvasive biomarkers of rejection are needed to improve the management of these patients. We assessed whether total cell-free DNA (tCF-DNA) and donor-derived cell-free DNA (ddCF-DNA) were useful markers for this purpose, both in plasma and in urine.

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