Open AccessSimultaneous Screening and Quantification of 29 Drugs of Abuse in Oral Fluid by Solid-Phase Extraction and Ultraperformance LC-MS/MS
Author(s) -
Nora Badawi,
Kirsten Wiese Simonsen,
Anni Steentoft,
Inger Marie Bernhoft,
Kristían Línnet
Publication year - 2009
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2008.122341
Subject(s) - chromatography , chemistry , benzoylecgonine , solid phase extraction , extraction (chemistry) , sample preparation , high performance liquid chromatography , codeine , electrospray ionization , ammonium acetate , triple quadrupole mass spectrometer , mass spectrometry , selected reaction monitoring , tandem mass spectrometry , metabolite , pharmacology , medicine , biochemistry , morphine
The European DRUID (Driving under the Influence of Drugs, Alcohol And Medicines) project calls for analysis of oral fluid (OF) samples, collected randomly and anonymously at the roadside from drivers in Denmark throughout 2008-2009. To analyze these samples we developed an ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for detection of 29 drugs and illicit compounds in OF. The drugs detected were opioids, amphetamines, cocaine, benzodiazepines, and Delta-9-tetrahydrocannabinol.
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