Measurement of Ribosomal RNA Turnover In Vivo by Use of Deuterium-Labeled Glucose | Zendy

Julien Defoiche | Zendy; Yan Zhang | Zendy; Laurence Lagneaux | Zendy; Ruth Pettengell | Zendy; Andrea M. Hegedus | Zendy; Luc Willems | Zendy; Derek C. Macallan | Zendy

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Measurement of Ribosomal RNA Turnover In Vivo by Use of Deuterium-Labeled Glucose

Author(s) -

Julien Defoiche,

Yan Zhang,

Laurence Lagneaux,

Ruth Pettengell,

Andrea M. Hegedus,

Luc Willems,

Derek C. Macallan

Publication year - 2009

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2008.119446

Subject(s) - in vivo , rna , ribosomal rna , in vitro , chemistry , rna extraction , microbiology and biotechnology , biochemistry , biology , gene

Most methods for estimation of rates of RNA production are not applicable in human in vivo clinical studies. We describe here an approach for measuring ribosomal RNA turnover in vivo using [6,6-(2)H(2)]-glucose as a precursor for de novo RNA synthesis. Because this method involves neither radioactivity nor toxic metabolites, it is suitable for human studies.

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