Circulating Prostate Tumor Cells Detected by Reverse Transcription-PCR in Men with Localized or Castration-Refractory Prostate Cancer: Concordance with CellSearch Assay and Association with Bone Metastases and with Survival | Zendy

Pauliina Helo | Zendy; Angel M. Cronin | Zendy; Daniel C. Danila | Zendy; Sven Wenske | Zendy; Rita Gonzalez-Espinoza | Zendy; Aseem Anand | Zendy; Michael Koscuiszka | Zendy; RiinaMinna Väänänen | Zendy; Kim Pettersson | Zendy; Felix K.H. Chun | Zendy; Thomas Steuber | Zendy; Hartwig Huland | Zendy; Bertrand Guillonneau | Zendy; James A. Eastham | Zendy; Peter T. Scardino | Zendy; Martin Fleisher | Zendy; Howard I. Scher | Zendy; Hans Lilja | Zendy

Open Access

Circulating Prostate Tumor Cells Detected by Reverse Transcription-PCR in Men with Localized or Castration-Refractory Prostate Cancer: Concordance with CellSearch Assay and Association with Bone Metastases and with Survival

Author(s) -

Pauliina Helo,

Angel M. Cronin,

Daniel C. Danila,

Sven Wenske,

Rita Gonzalez-Espinoza,

Aseem Anand,

Michael Koscuiszka,

RiinaMinna Väänänen,

Kim Pettersson,

Felix K.H. Chun,

Thomas Steuber,

Hartwig Huland,

Bertrand Guillonneau,

James A. Eastham,

Peter T. Scardino,

Martin Fleisher,

Howard I. Scher,

Hans Lilja

Publication year - 2009

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2008.117952

Subject(s) - concordance , prostate cancer , medicine , oncology , prostate , cancer , pathology

Reverse transcription-PCR (RT-PCR) assays have been used for analysis of circulating tumor cells (CTCs), but their clinical value has yet to be established. We assessed men with localized prostate cancer or castration-refractory prostate cancer (CRPC) for CTCs via real-time RT-PCR assays for KLK3 [kallikrein-related peptidase 3; i.e., prostate-specific antigen (PSA)] and KLK2 mRNAs. We also assessed the association of CTCs with disease characteristics and survival.

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