Only Large Reductions in Concentrations of Natriuretic Peptides (BNP and NT-proBNP) Are Associated with Improved Outcome in Ambulatory Patients with Chronic Heart Failure | Zendy

Wayne L. Miller | Zendy; Karen Hartman | Zendy; Diane E. Grill | Zendy; John C. Burnett | Zendy; Allan S. Jaffe | Zendy

Open Access

Only Large Reductions in Concentrations of Natriuretic Peptides (BNP and NT-proBNP) Are Associated with Improved Outcome in Ambulatory Patients with Chronic Heart Failure

Author(s) -

Wayne L. Miller,

Karen Hartman,

Diane E. Grill,

John C. Burnett,

Allan S. Jaffe

Publication year - 2008

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2008.108928

Subject(s) - medicine , natriuretic peptide , heart failure , hazard ratio , ambulatory , cardiology , heart transplantation , brain natriuretic peptide , confidence interval

Concentrations of B-type natriuretic peptides (BNPs), including N-terminal pro-B-type natriuretic peptide (NT-proBNP), can be used to estimate prognosis in chronic heart failure. Large biologic variability, however, limits the usefulness of serial measurements in individual patients. As a result, the magnitude of change in peptide concentrations that is clinically meaningful remains to be established.

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