Open AccessState-of-the-Art of Serum Testosterone Measurement by Isotope Dilution–Liquid Chromatography– Tandem Mass Spectrometry
Author(s) -
Linda M. Thienpont,
Katleen Van Uytfanghe,
Stuart Blincko,
Carol Ramsay,
Hui Xie,
Robert C. Doss,
Brian Keevil,
Laura Owen,
Alan L. Rockwood,
Mark M. Kushnir,
Kelly Y. Chun,
Donald Walt Chandler,
H P Field,
Patrick M. Sluss
Publication year - 2008
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2008.105841
Subject(s) - chromatography , isotope dilution , chemistry , mass spectrometry , tandem mass spectrometry , liquid chromatography–mass spectrometry , accuracy and precision , correlation coefficient , mathematics , statistics
The recent interest of clinical laboratories in developing serum testosterone assays based on isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) stems from the lack of accuracy of direct immunoassays. In this study, we assessed the accuracy and state of standardization (traceability) of 4 published ID-LC-MS/MS procedures in a method comparison with an ID-gas chromatography (GC)-MS reference measurement procedure listed in the database of the Joint Committee for Traceability in Laboratory Medicine.
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