Open AccessHighly Multiplexed Genotyping of Thiopurine S-Methyltransferase Variants Using MALDI-TOF Mass Spectrometry: Reliable Genotyping in Different Ethnic Groups
Author(s) -
Elke Schaeffeler,
Ulrich M. Zanger,
Michel Eichelbaum,
S. Asante-Poku,
JaeGook Shin,
Matthias Schwab
Publication year - 2008
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2008.103457
Subject(s) - thiopurine methyltransferase , genotyping , multiplex , genotype , population , allele frequency , biology , microbiology and biotechnology , genetics , medicine , gene , inflammatory bowel disease , disease , environmental health
To avoid severe hematotoxicity in patients, determination of the TPMT (thiopurine S-methyltransferase) genotype before commencing thiopurine therapy has become accepted.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom