Direct Determination of Lipoprotein Particle Sizes and Concentrations by Ion Mobility Analysis | Zendy

Michael P. Caulfield | Zendy; Shuguang Li | Zendy; Gloria Lee | Zendy; Patricia J. Blanche | Zendy; Wael Salameh | Zendy; W. Henry Benner | Zendy; Richard E. Reitz | Zendy; Ronald M. Krauss | Zendy

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Direct Determination of Lipoprotein Particle Sizes and Concentrations by Ion Mobility Analysis

Author(s) -

Michael P. Caulfield,

Shuguang Li,

Gloria Lee,

Patricia J. Blanche,

Wael Salameh,

W. Henry Benner,

Richard E. Reitz,

Ronald M. Krauss

Publication year - 2008

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.100586

Subject(s) - lipoprotein particle , lipoprotein , apolipoprotein b , particle size , very low density lipoprotein , particle (ecology) , chemistry , lipoprotein(a) , range (aeronautics) , coefficient of variation , cholesterol , reference range , chromatography , medicine , materials science , biochemistry , biology , ecology , composite material

Current methods for measuring the concentrations of lipoprotein particles and their distributions in particle subpopulations are not standardized. We describe here and validate a new gas-phase differential electrophoretic macromolecular mobility-based method (ion mobility, or IM) for direct quantification of lipoprotein particles, from small, dense HDL to large, buoyant, very-low-density lipoprotein (VLDL).

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