Use of Proximity Ligation to Screen for Inhibitors of Interactions between Vascular Endothelial Growth Factor A and Its Receptors | Zendy

Sigrun Gustafsdottir | Zendy; Stefan Wennström | Zendy; Simon Fredriksson | Zendy; Edith Schallmeiner | Zendy; Andrew D. Hamilton | Zendy; Saı̈d M. Sebti | Zendy; Ulf Landegren | Zendy

Open Access

Use of Proximity Ligation to Screen for Inhibitors of Interactions between Vascular Endothelial Growth Factor A and Its Receptors

Author(s) -

Sigrun Gustafsdottir,

Stefan Wennström,

Simon Fredriksson,

Edith Schallmeiner,

Andrew D. Hamilton,

Saı̈d M. Sebti,

Ulf Landegren

Publication year - 2008

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.099424

Subject(s) - aptamer , proximity ligation assay , receptor , monoclonal antibody , recombinant dna , chemistry , vascular endothelial growth factor , kinase insert domain receptor , reagent , microbiology and biotechnology , ic50 , biochemistry , pharmacology , antibody , vegf receptors , biology , cancer research , vascular endothelial growth factor a , immunology , in vitro , gene

Improved methods are required to screen drug candidates for their influences on protein interactions. There is also a compelling need for miniaturization of screening assays, with attendant reductions in reagent consumption and assay costs.

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